Fetal asphyctic preconditioning alters the transcriptional response to perinatal asphyxia
نویسندگان
چکیده
منابع مشابه
Brain apoptosis and carotid artery reactivity in fetal asphyctic preconditioning.
We aimed to develop a model of fetal hypoxia-ischemia (HI) preconditioning that reflects the pathophysiological conditions of perinatal asphyxia more closely than the existing neonatal stroke models. Fetal asphyxia (FA) was induced by clamping the uterine vasculature on embryonic day E17. At birth (P0), severe perinatal asphyxia (SPA) was induced during cesarean section. At P4, carotid arteries...
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BACKGROUND Perinatal asphyxia is known to precipitate myocardial dysfunction, rhythm abnormalities and congestive cardiac failure. CASE CHARACTERISTICS A 2-day old neonate with perinatal asphyxia. OBSERVATION He developed shock secondary to ventricular tachycardia, and required synchronized cardioversion for reversion of abnormal rhythm. OUTCOME Reversal of arrhythmia leading to recovery....
متن کاملNeurological Complications of Perinatal Asphyxia
The degree of asphyxia is best ascertained by measuring the amount of fetal acidosis determined by umbilical arterial blood. An umbilical arterial pH of less than 7.0 is seen in about 0.3% of deliveries.1 It indicates a severity of acidosis that places the fetus at risk for permanent neurological damage because of asphyxia. However, the outcome of infants with umbilical cord pH of less than 7.0...
متن کاملChromosomal aberrations in Perinatal Asphyxia
This study was conducted to evaluate the level of chromosomal damage in perinatal asphyxia and correlate it with severity of asphyxia. Fourty term neonates with asphyxia and twenty term babies without asphyxia were included in this case control study. Blood samples were collected within 24 hours of birth for karyotyping and oxidative stress by serum malondealdehyde (MDA) estimation. The degree ...
متن کاملNeuroprotective treatment for perinatal asphyxia.
BACKGROUND Perinatal asphyxia can cause serious illness or death. By taking steps in the «latent phase», which occurs 6-24 hours after the hypoxic event, the neurological damage caused by perinatal asphyxia can be limited. We wish to present a selection of such measures that are either established treatment today or that appear promising. METHOD We searched in the Medline and Cochrane Library...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2014
ISSN: 1471-2202
DOI: 10.1186/1471-2202-15-67